Results
| PMID | 24246915 |
| Gene Name | CASP3 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 62 |
| Population details | 62 (32 patients with endometriosis, 30 women without endometriosis) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Zhonghua Bing Li Xue Za Zhi. 2013 Aug;42(8):515-8. Wei, Wei-dong| Ruan, Fei| Tu, Fei-xia| Zhou, Cai-yun| Lin, Jun Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China. OBJECTIVE: To investigate the expression of suppressor of cytokine signaling(SOCS)-3 and caspase-3 and their correlative significance in endometriosis. METHODS: Immunohistochemical EnVision method was used to detect the SOCS-3 and caspase-3 protein expression in ectopic and eutopic endometrium (n = 32) of patients with endometriosis, as well as normal endometrium (n = 30) of women without endometriosis. RESULTS: SOCS-3 and caspase-3 proteins were expressed in all three groups and not affected by the menstrual cycles. The expression of SOCS-3 in ectopic endometrium (5.54 +/- 2.12) was significantly lower than that in eutopic (7.39 +/- 1.09, P = 0.001) and control group (7.48 +/- 1.26, P < 0.01), but without difference between the eutopic and control group (P = 0.756). SOCS-3 expression in ectopic and eutopic endometrium was significantly lower in III/IV stages than that in I/II stages of endometriosis (P < 0.05). Significantly lower expression of caspase-3 protein was found in ectopic (3.20 +/- 1.24) and eutopic endometrium (3.88 +/- 1.93) as compared with the control group (6.49 +/- 1.85, P < 0.01), however ectopic and eutopic endometrium showed no significant difference (t = 1.66, P = 0.10). There was no significant difference of the expression of caspase-3 in ectopic and eutopic endometrium at different disease stages (P > 0.05). Positive correlation was found between the expression of SOCS-3 and caspase-3 proteins in ectopic endometrium (r = 0.655, P < 0.01). CONCLUSION: SOCS-3 may be involved in the development of endometriosis through inhibition of apoptosis of ectopic endometrial cells. Mesh Terms: Adult| Caspase 3/*metabolism| Endometriosis/*metabolism/pathology| Endometrium/*metabolism/pathology| Female| Humans| Immunohistochemistry| Menstrual Cycle| Middle Aged| Suppressor of Cytokine Signaling 3 Protein| Suppressor of Cytokine Signalin |
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